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U.S launches Clinical Trial For HIV Vaccine That Uses mRNA Technology

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Experimental mRNA HIV vaccine shows promise in pre-clinical studies

A biotech firm in U.S announced Thursday that it’s launched early-stage clinical trials of an HIV mRNA vaccine.

Moderna has teamed up with the nonprofit International AIDS Vaccine Initiative to develop the shot, which uses the same technology as Moderna’s successful COVID-19 vaccine.

The first participants in the Phase I trial were given doses at George Washington University School of Medicine and Health Sciences in Washington, D.C., according to a company statement.

“We are tremendously excited to be advancing this new direction in HIV vaccine design with Moderna’s mRNA platform,” Dr. Mark Feinberg, president and CEO of IAVI, said in a statement. “The search for an HIV vaccine has been long and challenging, and having new tools in terms of immunogens and platforms could be the key to making rapid progress toward an urgently needed, effective HIV vaccine.”j

Nearly 38 million people worldwide — including about 1.3 million in the U.S — are living with HIV, or human immunodeficiency virus, which can lead to the potentially fatal disease AIDS.

Being diagnosed with HIV was once considered a death sentence. During the height of the U.S. AIDS epidemic in the mid-1990s, more than 50,000 deaths occurred every year, according to the Centers for Disease Control and Prevention.

Today, HIV is much more manageable with medications that can reduce viral loads to undetectable so the virus can’t be transmitted, as well as pills that can be taken to prevent infecting those who are HIV-negative.

But despite decades of research, no vaccine has ever been developed. Several candidates have entered clinical trials but failed in later stages.

The new vaccine uses mRNA, or messenger RNA, which teaches the body’s cells how to make proteins that trigger immune responses.

Researchers have developed not only a primary vaccine but also a booster to deliver HIV immunogens — molecules that elicit an immune response — via mRNA.

The hope is this process can induce specific white blood cells, called B cells, which can then turn into what are known as broadly neutralizing antibodies that can neutralize the virus.

According to the statement, Phase I of the trial will enroll 56 healthy, HIV-negative adult participants at GWU and three additional sites: Hope Clinic of Emory Vaccine Center in Atlanta; Fred Hutchinson Cancer Research Center in Seattle; and the University of Texas-Health Science Center at San Antonio.

Of the volunteers, 48 will receive one or two doses of the mRNA vaccine, and 32 also will receive the booster. The remaining eight will receive just the booster.

Source: ABC News’ Sony Salzman.

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I Wrote One Of The Biggest Songs In The World For A Nigerian Artiste – Kuami Eugene

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📸: Kuami Eugene

Three times Highlife Artist of the year Kuami Eugene has revealed that he is the ghostwriter for one of the most viral songs in West Africa.

Rockstar Eugene visited Giovani Caleb on the 3FM Drive where he disclosed that he wrote one of the most viral songs in Africa for a popular Nigerian artist.

He kept details of the name of the artist and the title of the song to himself but hinted that it ranks among the top 5 viral songs on TikTok.

Kuami Eugene added that he does not regret writing the song for the Nigerian artist because he was paid handsomely for his work.

The Lynx Entertainment Signee has worked with a number of Nigerian musicians but his recent work was on the viral song with CKay.

Eugene could not confirm or deny if that was the song he wrote, all he could say was CKay owns the rights to the song.

Kuami Eugene’s new song ‘Take Away’ is out and streaming on all music platforms.

SOURCE: 3NEWS

 

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Johnny Depp trial LIVE: Day 22 Of Defamation Battle With Amber Heard

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Hello and welcome to this Wednesday’s live blog on the trial involving Johnny Depp and Amber Heard.

After a long battle, we are now in what could be the last week of proceedings. Depp and Heard have both taken to the stand, and now there is a focus on what the witnesses have to say, as well as those close to the former married couple.

It was thought that Depp could be asked to return to the stand, having done so in the early part of the trial, but it appears as though Heard‘s camp have changed tact and will not do this.

One well-known person who is expected to give evidence via a video link today is Kate Moss, Depp’s ex-girlfriend.

The reason for the trial is that Depp is suing Heard for a sum of 50 million dollars due to a domestic abuse column she wrote in the Washington Post in 2018, while she countersued for 100 million dollars.

Throughout the course of day, you will be able to see the latest news surrounding the Depp-Heard trial, as well as updates from the courtroom in Fairfax, Virginia.

The trial is in progress. Watch Live : Johnny Depp Amber Heard Trial

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Caitlyn Jenner Says Kanye West Was ‘Very Difficult to Live With’ During Marriage to Kim Kardashian

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Dimitrios Kambouris/GI for The Met Museum/Vogue/ source: Billboard.com

Caitlyn Jenner opened up about Kim Kardashian‘s romantic relationships as a guest on The Pivot Podcast on Tuesday (May 24), and shared her thoughts about her former stepdaughter’s estranged husband Kanye West and her current boyfriend Pete Davidson.

“He was very difficult to live with,” Jenner said of West, though she added that the rapper supported her when she transitioned back in 2015.

“Actually, I’m really into Pete right now with Kim,” she shifted gears, talking about the SNL star’s growing relationship with Kardashian. “We have a comedian in the family. Yay! We don’t need more rappers. We need a comedian in the family.”

Kardashian began dating Davidson in the fall, soon after she hosted Saturday Night Liveand nearly a year after she filed for divorce from Ye. The former couple, who tied the knot in May 2014, share four children: North, Saint, Chicago, and Psalm.

Jenner shared that she ended up meeting the 28-year-old comedian when the Skims founder brought him to the former Olympian’s Malibu home recently. “[Davidson is] very different than what she would normally date, but Kimberly has been through a lot with the guys she’s been with, especially Kanye,” she said. “Pete is 180 degrees in the other direction. First of all, he treats her so well, and when they were over here, Kim [was] so happy, and Kim deserves to be happy.”

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